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Group Sequential Methods with Applications to Clinical Trials (Chapman & Hall/CRC Interdisciplinary Statistics)

Christopher Jennison, Bruce W. Turnbull




[PDF.lg90] Group Sequential Methods with Applications to Clinical Trials (Chapman & Hall/CRC Interdisciplinary Statistics)

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 | #444507 in Books |  Christopher Jennison |  1999-09-15 | Original language:English | PDF # 1 |  9.21 x.94 x6.14l,1.50 | File type: PDF | 416 pages

 | Group Sequential Methods with Applications to Clinical Trials

||28 of 28 people found the following review helpful.| first good text on group sequential methods|By Michael R. Chernick|Advances in the theory of repeated significance testing in the 1980s and 1990s has made sequential methods practical by identifying stopping rules for data collected sequentially but in groups. This material is now used to plan interim analyses and both safety and efficacy group sequential trials for clinical

Group sequential methods answer the needs of clinical trial monitoring committees who must assess the data available at an interim analysis. These interim results may provide grounds for terminating the study-effectively reducing costs-or may benefit the general patient population by allowing early dissemination of its findings. Group sequential methods provide a means to balance the ethical and financial advantages of stopping a study early against the risk of an incorr...

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