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DNA Methylation and Cellular Differentiation (Cell Biology Monographs)

James H. Taylor




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 | #9512934 in Books |  2011-12-30 |  2013-10-04 | Original language:English | PDF # 1 |  9.61 x.35 x6.69l,.56 | File type: PDF | 138 pages

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In 1977 I wrote a grant proposal in which I applied to study developmental patterns in enzymatic methylation of DNA in eukaryotes. One part of the proposal was to assay cells at different embryonic developmental stages for maintenance and de novo type methylase activity. With one exception the referees, probably developmental biologists, recommended that the work not be supported because there was no evidence that methylation plays any role in eukaryotic gene regulation....

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