[PDF.37sg] Checkpoint Controls and Targets in Cancer Therapy (Cancer Drug Discovery and Development)

Checkpoint Controls and Targets in Cancer Therapy (Cancer Drug Discovery and Development)

[PDF.pl85] Checkpoint Controls and Targets in Cancer Therapy (Cancer Drug Discovery and Development)

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 | #7489973 in Books |  Humana Press |  2009-09-07 | Original language:English | PDF # 1 |  10.10 x.90 x7.20l,1.80 | File type: PDF | 274 pages

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Much work over the last two decades has firmly established that loss of cell cycle checkpoint regulation, and resultant unabated cellular proliferation, is an inherent characteristic of cancer. This loss may occur through aberration in any single component involved in signal transduction pathways that orchestrate checkpoint regulation, which may manifest through either a failure to activate the checkpoint or a failure to respond to the activated checkpoint. In normal ...

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