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Biomedical Informatics for Cancer Research

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 | #8313844 in Books |  Springer US |  2010-04-01 | Original language:English | PDF # 1 |  9.20 x1.00 x6.10l,1.45 | File type: PDF | 354 pages

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view, showing that multiple molecular pathways must be affected for cancer to develop, but with different specific proteins in each pathway mutated or differentially expressed in a given tumor (The Cancer Genome Atlas Research Network 2008; Parsons et al. 2008). Different studies demonstrated that while widespread mutations exist in cancer, not all mutations drive cancer development (Lin et al. 2007). This suggests a need to target only a deleterious subset of aberrant p...

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